黑料不打烊

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Dr Lea Dib

Lea Dib

Admission tutor for Biochemistry

Research centres and groups

National collaborators

  • Prof Claudia Monaco (University of Oxford)
  • Dr Felino Cagampang (University of Southampton)

Research projects

Dr. Dib’s research interest aims to investigate the molecular mechanisms and metabolic control of lipid-associated macrophages (LAMs-also known as foam cells) in different tissues and metabolic and non-metabolic disease.

Research plans involve:

  • Dissecting the mechanistic and signalling properties of LAMs.  Studying the overall immuno-metabolic signatures of LAM populations with a particle focus on investigating the signalling switch that promotes the transition from homeostatic to inflammatory LAMs.
  • Understanding the relevance of the different LAM populations in different tissues in health and disease.

Selected publications

  • Monaco C & Dib L Atheroimmunology: keeping the immune system in atherosclerosis in check. Nature Review Cardiology 2024 Nov;21(11):737-738.
  • Dib L, Koneva LA, Edsfeldt A, Zurke Y-X, Sun J, Nitulescu M, Attar M, Cassimjie I, Lee R, Handa A, Goncalves I, Sansom SN, Monaco C. Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications. Nature Cardiovascular Research 2023 Jun 26;2(7):656-672.
  • Forteza MJ, Berg M, Edsfeldt A, Sun J, Baumgartner R, Kareinen I, Casagrande FB, Hedin U, Zhang S, Vuckovic I, Dzeja PP, Polyzos KA, Gisterå A, Trauelsen M, Schwartz TW, Dib L, Herrmann J, Monaco C, Matic L, Gonçalves I, Ketelhuth DFJ. Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk. Cardiovascular Research 2023 July 4; 119(7):1524–1536.
  • Monaco C & Dib L. Breaking the macrophage code in atherosclerosis. Cardiovascular Research 2023 Jul 6; 119(8):1622-1623.
  • Monaco C & Dib L Modelling systemic risk factors in cardiovascular disease using single-cell biology. Nature Cardiovascular Research 2023 Jun 8; 2: 496–497.
  • de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Ylä-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C. Translational opportunities of single-cell biology in atherosclerosis. European Heart Journal 2023 Apr 7; 44(14):1216-1230.
  • COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. Cell 2022 Mar 3;185(5):916-938.
  • Edsfeldt A, Swart M, Singh P, Dib L, Sun J, Cole JE, Park I, Al-Sharify D, Persson A, Nitulescu M, Borges PDN, Kassiteridi C, Goddard ME, Lee R, Volkov P, Orho-Melander M, Maegdefessel L, Nilsson J, Udalova I, Goncalves I, Monaco C. Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques. European Heart Journal 2022 May 14;43(19):1864-1877.
  • Chimen M, Evryviadou A, Box CL, Harrison MJ, Hazeldine J, Dib LH, Kuravi SJ, Payne H, Price JMJ, Kavanagh D, Iqbal AJ, Lax S, Kalia N, Brill A, Thomas SG, Belli A, Crombie N, Adams RA, Evans S,Deckmyn H, Lord JM, Harrison P, Watson SP, Nash GB, RaingerGE. Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation. Haematologica 2020 May;105(5):1248-1261
  • Recio C, Lucy D, Purvis GSD, Iveson P, Zeboudj L, Iqbal AJ, Lin D, O’Callaghan C, Davison L, Griesbach E, RusselL AJ, Wynne GM, Dib L, Monaco C馉妸nd Greaves DR. Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages. Frontiers Immunology 2018 Jun 20; 9:1419
  • Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, Dib LH, Mol IM, Caengprasath N, Chan YW, Damak S, Reifel Miller A, Coskun T, Shimpukade B, Ulven T, Kooijman S, Rensen PCN, ChristianM. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. Embo Molecular Medicine 2018 Mar;10(3). pii: e8047
  • Chimen M, Yates CM, McGettrrick HM, Ward LS, Harrison MJ, Apta B, Dib LH, Imhof BA, Harrison P, Nash GB, Rainger GE. Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface. Journal of Immunology 2017 Apr 1;198(7):2834-2843.
  • Dib L, Ortega MT, Melgarejo T, Chapes SK. Establishment and characterization of DB-1: A leptin receptor-deficient murine macrophage cell line. Cytotechnology 2016 Aug;68(4):921-33.
  • Dib L, Bugge A, Collins S. LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes. Journal of Lipid Research 2014 Feb;55(2):247-57.
  • Bugge A, Dib L, Collins S. Measuring respiratory activity of adipocytes and adipose tissues in real time. Methods in Enzymology 2014; 538:233-47
  • Sellayah D, Dib L, Watkins AJ, Fleming TP, Hanson MA, Cagampang FR. Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding on diet-induced thermogenesis in adult mouse offspring. European Journal of Nutrition 2014; 53(7):1523-31.
  • Dib L, Ortega MT, Flemming SD, Chapes SK, Melgarejo T. Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice. Endocrinology 2014 Jan;155(1):40-6.
  • Linde A, Wachter B, Höner OP, Dib L, Ross C, Tamayo AR, Blecha F, Melgarejo T. Natural History of Innate Host Defense Peptides. Probiotics & Antimicro Prot 2009; 1: 97-112.
  • Linde A, Ross C, Davis E, Dib L, Blecha F, Melgarejo T. Innate immunity and host defense peptides in veterinary medicine. J Vet Inter Med 2008; 22 (2): 247-265.
  • El-Hajj Fuleihan G, Dib L, Yamout B, Sawaya R, Mikati M. Predictors of bone density in ambulatory patients on antiepileptic drugs. Bone 2008 Jul;43(1):149-55.
  • Mikati MA, Dib L, Yamout B, Sawaya R, Rahi AC, Fuleihan Gel-H. Two randomized vitamin D trials in ambulatory patients on anticonvulsants: impact on bone. Neurology 2006; 67:2005-2014.
  • Dib L, Arabi A, Nabulsi M, Maalouf J, El-Hajj Fuleihan. Impact of anthropometric, lifestyle and body composition variables on ultrasound measurements in school children. Bone 2005; 36:736-742.
  • Abou Samra R, Hwalla Baba N, Torbay N, Dib L, El-Hajj Fuleihan G. High Plasma Leptin is not associated with higher bone mineral density in insulin resistant premenopausal obese women. Journal of Clinical Endocrinology and Metabolism 2005; 90: 2588-94.

Publications

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